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Mixed Effect Models and Censoring

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lme4cens: Simple Linear Mixed Effect Models and Censoring

The R-package lme4cens builds on lme4 to fit simple random effects models with a censored response. It re-uses the formula-module from lme4 to facilitate model specification. The censoring information is encoded via survival's Surv-object that allows for a flexible specification of (a combination of) left-, right- and interval-censored responses with flexible censoring levels per observation.

The random effect structure is currently limited to the most simple case, namely models with a single random intercept. Model fitting is via maximum likelihood (ML), residual maximum likelihood (REML) is not supported.

A good choice of starting values is helpful, although there is a heuristic in place if none are given. As with all non-trivial optimization problems it is good practice to check convergence with different start values.

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