PELC is a Python package designed to calculate efficiently the HLA Eplet Load (based on the EpRegistry database) between donors and recipients. v0.5.4.4 of PELC includes the latest version of EpRegistry (V2025-02-01. IPD-IMGT/HLA: 3.59). The infamous 185I bug was fixed by the EpRegistry team, pelc is up to date in that regard too.