diff --git a/conftest.py b/conftest.py
index 265a447d02c..e74e741ee54 100644
--- a/conftest.py
+++ b/conftest.py
@@ -13,6 +13,21 @@
 # limitations under the License.
 
 
+def pytest_configure(config):
+    # Ignore deprecation warnings in python code generated from our protobuf definitions.
+    # Eventually, the warnings will be removed by upgrading protoc compiler. See issues
+    # #4161 and #4737.
+    for f in (
+        "FieldDescriptor",
+        "Descriptor",
+        "EnumDescriptor",
+        "EnumValueDescriptor",
+        "FileDescriptor",
+        "OneofDescriptor",
+    ):
+        config.addinivalue_line("filterwarnings", f"ignore:Call to deprecated create function {f}")
+
+
 def pytest_addoption(parser):
     parser.addoption(
         "--rigetti-integration",