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Currently PKNCA is unable to calculate parameter F (bioavailability). Until that feature has been implemented, we want a separate section (along with the rest of the ratio calculations) to calculate bioavailability. This should include the following options:
Auc_Ex_dn/AUC_IV_dn for individual subjects (if same subject has both samples)
AUC_EX.dn(ind) / AUC_IV.dn (Mean) (where different subjects have different routes)
F should be written as a ratio and as a percentage %
The user should be able to select which AUCs they would like to use: inf, obs, last, int etc.
The app should be able to automatically determine if there are subjects with both IV and EX routes for each group (taken from grouping_vars), or not, and decide which of 1 or 2 it will calculate. The mean should be calculated by the grouping vars. The results should be shown in a table with AUC1.dnEX, AUC.dn.IV, ratio, %. The type of AUC (mean or individual) should also be in the results.
Example table:
Definition of Done
The requirements for the feature to be complete:
Bioavailability calculation for individuals, and grouped data
Automatic calculations with only user input for parameters
Results table with ratios displayed
The text was updated successfully, but these errors were encountered:
Description
Currently PKNCA is unable to calculate parameter F (bioavailability). Until that feature has been implemented, we want a separate section (along with the rest of the ratio calculations) to calculate bioavailability. This should include the following options:
F should be written as a ratio and as a percentage %
The user should be able to select which AUCs they would like to use: inf, obs, last, int etc.
The app should be able to automatically determine if there are subjects with both IV and EX routes for each group (taken from
grouping_vars
), or not, and decide which of 1 or 2 it will calculate. The mean should be calculated by the grouping vars. The results should be shown in a table with AUC1.dnEX, AUC.dn.IV, ratio, %. The type of AUC (mean or individual) should also be in the results.Example table:
Definition of Done
The requirements for the feature to be complete:
The text was updated successfully, but these errors were encountered: