Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Enhancement: bioavailability calculations #203

Open
3 tasks
js3110 opened this issue Feb 11, 2025 · 1 comment
Open
3 tasks

Enhancement: bioavailability calculations #203

js3110 opened this issue Feb 11, 2025 · 1 comment
Assignees
Labels
enhancement New feature or request

Comments

@js3110
Copy link
Collaborator

js3110 commented Feb 11, 2025

Description

Currently PKNCA is unable to calculate parameter F (bioavailability). Until that feature has been implemented, we want a separate section (along with the rest of the ratio calculations) to calculate bioavailability. This should include the following options:

  1. Auc_Ex_dn/AUC_IV_dn for individual subjects (if same subject has both samples)
  2. AUC_EX.dn(ind) / AUC_IV.dn (Mean) (where different subjects have different routes)
  3. AUC_EX.dn(Mean) / AUC_IV.dn(Mean) (as summary statistics)

F should be written as a ratio and as a percentage %

The user should be able to select which AUCs they would like to use: inf, obs, last, int etc.
The app should be able to automatically determine if there are subjects with both IV and EX routes for each group (taken from grouping_vars), or not, and decide which of 1 or 2 it will calculate. The mean should be calculated by the grouping vars. The results should be shown in a table with AUC1.dnEX, AUC.dn.IV, ratio, %. The type of AUC (mean or individual) should also be in the results.

Example table:

Image

Definition of Done

The requirements for the feature to be complete:

  • Bioavailability calculation for individuals, and grouped data
  • Automatic calculations with only user input for parameters
  • Results table with ratios displayed
@js3110 js3110 added the enhancement New feature or request label Feb 11, 2025
@js3110 js3110 added this to aNCA Feb 11, 2025
@js3110 js3110 moved this to Todo in aNCA Feb 11, 2025
@js3110
Copy link
Collaborator Author

js3110 commented Feb 11, 2025

This issue is linked to #116 , and will also be created in the same tab as #191

@js3110 js3110 mentioned this issue Feb 14, 2025
9 tasks
@js3110 js3110 moved this from Todo to In Progress in aNCA Feb 21, 2025
@js3110 js3110 self-assigned this Feb 21, 2025
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
enhancement New feature or request
Projects
Status: In Progress
Development

When branches are created from issues, their pull requests are automatically linked.

1 participant