diff --git a/tests/integration/cli/commands/test_cache_prune.py b/tests/integration/cli/commands/test_cache_prune.py
index 2ba2fbe03..48618d80f 100644
--- a/tests/integration/cli/commands/test_cache_prune.py
+++ b/tests/integration/cli/commands/test_cache_prune.py
@@ -27,6 +27,7 @@
 )
 from pex.cli.commands.cache.du import DiskUsage
 from pex.common import environment_as, safe_open
+from pex.os import WINDOWS
 from pex.pep_503 import ProjectName
 from pex.pex_info import PexInfo
 from pex.pip.version import PipVersion, PipVersionValue
@@ -40,6 +41,15 @@
     from typing import Iterable, Iterator, Optional
 
 
+pytestmark = pytest.mark.skipif(
+    WINDOWS,
+    reason=(
+        "These tests (in particular `test_nothing_prunable`) currently hang on Windows in CI "
+        "regularly."
+    ),
+)
+
+
 @pytest.fixture(autouse=True)
 def pex_root(tmpdir):
     # type: (Tempdir) -> Iterator[str]