diff --git a/src/libraries/System.Runtime.Numerics/src/System/Numerics/BigInteger.cs b/src/libraries/System.Runtime.Numerics/src/System/Numerics/BigInteger.cs
index ad88153227d40b..62fc443b8d4bc6 100644
--- a/src/libraries/System.Runtime.Numerics/src/System/Numerics/BigInteger.cs
+++ b/src/libraries/System.Runtime.Numerics/src/System/Numerics/BigInteger.cs
@@ -1183,16 +1183,12 @@ public int CompareTo(BigInteger other)
                     return _sign < other._sign ? -1 : _sign > other._sign ? +1 : 0;
                 return -other._sign;
             }
-            int cuThis, cuOther;
-            if (other._bits == null || (cuThis = _bits.Length) > (cuOther = other._bits.Length))
+
+            if (other._bits == null)
                 return _sign;
-            if (cuThis < cuOther)
-                return -_sign;
 
-            int cuDiff = GetDiffLength(_bits, other._bits, cuThis);
-            if (cuDiff == 0)
-                return 0;
-            return _bits[cuDiff - 1] < other._bits[cuDiff - 1] ? -_sign : _sign;
+            int bitsResult = BigIntegerCalculator.Compare(_bits, other._bits);
+            return _sign < 0 ? -bitsResult : bitsResult;
         }
 
         public int CompareTo(object? obj)
@@ -3117,16 +3113,6 @@ private bool GetPartsForBitManipulation(Span<uint> xd)
             return _sign < 0;
         }
 
-        internal static int GetDiffLength(uint[] rgu1, uint[] rgu2, int cu)
-        {
-            for (int iv = cu; --iv >= 0;)
-            {
-                if (rgu1[iv] != rgu2[iv])
-                    return iv + 1;
-            }
-            return 0;
-        }
-
         [Conditional("DEBUG")]
         private void AssertValid()
         {
diff --git a/src/libraries/System.Runtime.Numerics/src/System/Numerics/BigIntegerCalculator.Utils.cs b/src/libraries/System.Runtime.Numerics/src/System/Numerics/BigIntegerCalculator.Utils.cs
index 30433dabf80494..47c0738ed1299b 100644
--- a/src/libraries/System.Runtime.Numerics/src/System/Numerics/BigIntegerCalculator.Utils.cs
+++ b/src/libraries/System.Runtime.Numerics/src/System/Numerics/BigIntegerCalculator.Utils.cs
@@ -1,6 +1,8 @@
 // Licensed to the .NET Foundation under one or more agreements.
 // The .NET Foundation licenses this file to you under the MIT license.
 
+using System.Diagnostics;
+
 namespace System.Numerics
 {
     internal static partial class BigIntegerCalculator
@@ -15,22 +17,18 @@ internal const
 
         public static int Compare(ReadOnlySpan<uint> left, ReadOnlySpan<uint> right)
         {
-            if (left.Length < right.Length)
-                return -1;
-            if (left.Length > right.Length)
-                return 1;
+            Debug.Assert(left.Length <= right.Length || left.Slice(right.Length).ContainsAnyExcept(0u));
+            Debug.Assert(left.Length >= right.Length || right.Slice(left.Length).ContainsAnyExcept(0u));
 
-            for (int i = left.Length - 1; i >= 0; i--)
-            {
-                uint leftElement = left[i];
-                uint rightElement = right[i];
-                if (leftElement < rightElement)
-                    return -1;
-                if (leftElement > rightElement)
-                    return 1;
-            }
+            if (left.Length != right.Length)
+                return left.Length < right.Length ? -1 : 1;
+
+            int iv = left.Length;
+            while (--iv >= 0 && left[iv] == right[iv]) ;
 
-            return 0;
+            if (iv < 0)
+                return 0;
+            return left[iv] < right[iv] ? -1 : 1;
         }
 
         private static int ActualLength(ReadOnlySpan<uint> value)
diff --git a/src/libraries/System.Runtime.Numerics/tests/BigInteger/Comparison.cs b/src/libraries/System.Runtime.Numerics/tests/BigInteger/Comparison.cs
index b6ce8a2e96cde3..d7bd371b3cf271 100644
--- a/src/libraries/System.Runtime.Numerics/tests/BigInteger/Comparison.cs
+++ b/src/libraries/System.Runtime.Numerics/tests/BigInteger/Comparison.cs
@@ -344,6 +344,40 @@ private static void RunPositiveTests(Random random)
 
             BigInteger b1 = new BigInteger(byteArray);
             VerifyComparison(BigInteger.One, false, b1 / b1, false, 0);
+
+            // BigIntegers constructed with a byte[]
+            {
+                int byteLength = 17;
+                var byteArray1 = new byte[byteLength];
+                var byteArray2 = new byte[byteLength];
+
+                byteArray1.AsSpan().Fill(1);
+                byteArray2.AsSpan().Fill(1);
+
+                // Equals
+                byteArray1[0] = 2;
+                byteArray2[0] = 2;
+                VerifyComparison(new BigInteger(byteArray1), false, new BigInteger(byteArray2), false, 0);
+                VerifyComparison(new BigInteger(byteArray1), true, new BigInteger(byteArray2), true, 0);
+                VerifyComparison(new BigInteger(byteArray1), false, new BigInteger(byteArray2), true, 1);
+                VerifyComparison(new BigInteger(byteArray1), true, new BigInteger(byteArray2), false, -1);
+
+                // Smaller
+                byteArray1[0] = 2;
+                byteArray2[0] = 3;
+                VerifyComparison(new BigInteger(byteArray1), false, new BigInteger(byteArray2), false, -1);
+                VerifyComparison(new BigInteger(byteArray1), true, new BigInteger(byteArray2), true, 1);
+                VerifyComparison(new BigInteger(byteArray1), false, new BigInteger(byteArray2), true, 1);
+                VerifyComparison(new BigInteger(byteArray1), true, new BigInteger(byteArray2), false, -1);
+
+                // Larger
+                byteArray1[0] = 3;
+                byteArray2[0] = 2;
+                VerifyComparison(new BigInteger(byteArray1), false, new BigInteger(byteArray2), false, 1);
+                VerifyComparison(new BigInteger(byteArray1), true, new BigInteger(byteArray2), true, -1);
+                VerifyComparison(new BigInteger(byteArray1), false, new BigInteger(byteArray2), true, 1);
+                VerifyComparison(new BigInteger(byteArray1), true, new BigInteger(byteArray2), false, -1);
+            }
         }
 
         private static void RunNegativeTests(Random random)
@@ -636,7 +670,7 @@ private static void VerifyComparison(BigInteger x, bool IsXNegative, BigInteger
             Assert.Equal(expectedGreaterThan || expectedEquals, x >= y);
             Assert.Equal(expectedLessThan || expectedEquals, y >= x);
         }
-        
+
         private static void VerifyCompareResult(int expected, int actual)
         {
             if (0 == expected)