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<!doctype html><html lang=en-us><head><meta name=generator content="Hugo 0.101.0"><meta charset=utf-8><meta http-equiv=x-ua-compatible content="IE=edge"><meta name=viewport content="width=device-width,initial-scale=1"><title>Miller-Jensen Lab at Yale</title><script async src="https://www.googletagmanager.com/gtag/js?id=UA-122839327-1"></script>
<script>window.dataLayer=window.dataLayer||[];function gtag(){dataLayer.push(arguments)}gtag("js",new Date),gtag("config","UA-122839327-1")</script><link href='//fonts.googleapis.com/css?family=PT+Sans+Narrow|PT+Serif|Shadows+Into+Light' rel=stylesheet type=text/css><link rel=stylesheet href=./style.a988950205b1244a0f6d9d10f1adfe2165e3f468602c0899342e52cda201e310.css media=screen></head><body><header id=header-row><div class=container><div id=lab-name><a href=./><h1><em>Miller<span class=dash>–</span>Jensen</em> Laboratory</h1><h2>at Yale Biomedical Engineering</h2></a></div><div><ul class=nav><li class=active><a href=./>Home</a></li><li><a href=./people/>People</a></li><li><a href=./publications/>Publications</a></li><li><a href=./news/>News</a></li></ul></div></div></header><main><div class="container miller-jensen lab at yale"><div id=tagline><p id=westudy>We study how
<em>cell signaling pathways</em> and
<em>cell-cell communication networks</em> regulate
<em>immune cell behavior</em></p><p id=weuse>...using tools from
<em>engineering</em>,
<em>biology</em>, and
<em>computer science</em>.</p><img src="data:image/png;base64,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"></div><div id=main-image-holder><script>const pictures=[{src:"macrophage.jpg",alt:"A macrophage from NIAID",credit:"Photo from https://www.flickr.com/photos/niaid/"},{src:"macrophage2.jpg",alt:"A macrophage from NIAID",credit:"Photo from https://www.flickr.com/photos/niaid/"},{src:"macrophage3.png",alt:"A macrophage from NIAID",credit:"Photo from https://www.flickr.com/photos/niaid/"},{src:"MedRF_29361.jpg",alt:"Virus image copright MedicalRF.com",credit:"Photo from https://www.MedicalRF.com"}],picture=pictures[Math.floor(Math.random()*pictures.length)],newImg=document.createElement("img");newImg.className="box-rotate-15 large-shadow hidden-xs hidden-sm",newImg.setAttribute("alt",picture.alt),newImg.setAttribute("src","./img/"+picture.src),document.getElementById("main-image-holder").appendChild(newImg)</script></div><div id=lab-description><p><span class=firstLetter><span>T</span></span>
<span class=remainderletters>he Miller-Jensen laboratory</span> uses a systems immunology approach: we combine quantitative experiments with integrated
computational analyses to account for the multiple molecular and cellular processes, non-linear outputs, and complex
intercellular interactions that ultimately enable robust immune regulation. We are specifically focused on the sources
and consequences of cellular response diversity. Considering the precision of immune cell responses to diverse pathogenic
threats, it is counterintuitive that genetically identical immune cells respond to perturbations with a high degree
of cell-to- cell variability, or “noise”; but recent research makes clear that this variability is an indispensable
feature of immune system function.</p><p><em>Heterogeneity of macrophage communication behavior.</em> Macrophages are cells of the innate immune system that perform
a range of functions important in host defense against pathogens. To carry out diverse functions, macrophages maintain
a functional plasticity, or flexibility, in their responses to microenvironmental stimuli, and we hypothesize this
is partially enabled by cell-to-cell heterogeneity. We are studying how heterogeneous macrophage subsets coordinate
activation of neighboring macrophages and other cells via paracrine signaling in response to pathogens and in the tumor
microenvironment.</p><p><em>Regulatory logic of signal–response relationships.</em> We are also interested in the mechanisms that regulate cell-to-cell
variability. Single-cell analyses provide a direct way to evaluate signal–response relationships. As a centrally important
example, we focus on the NF-κB pathway, which regulates both endogenous inflammatory genes in macrophages and HIV gene
expression in T cells. We are studying how targeting cell-to-cell response variability can modulate phenotypic outcomes
in these contexts.</p></div><div><h3>About Prof. Miller–Jensen</h3><p><img id=kmj class="box-rotate-10 small-shadow hidden-xs" height=317 width=200 src=./img/kmj.jpg> Kathryn is an Associate
Professor of Biomedical Engineering at Yale. Before joining
the faculty, she was an NIH Postdoctoral Fellow at <a href=http://www.Berkeley.edu>UC Berkeley</a> in the <a href=http://www.cchem.berkeley.edu/schaffer/>Schaffer
laboratory</a>.</p><p>Kathryn worked previously at the <a href=http://www.nationalacademies.org/>National Academies</a>,
<a href=http://www.merck.com/>Merck Pharmaceuticals</a>,
the<a href=http://english.cas.cn/> Chinese Academy of
Sciences,</a> and <a href=http://www.monitor.com/>Monitor
Group</a>. She
received
her Ph.D. in Chemical Engineering at <a href=http://web.mit.edu>MIT</a> with <a href=http://web.mit.edu/dallab>Doug Lauffenburger</a>. and
her B.E. & B.A. degrees at <a href=http://www.Dartmouth.edu>Dartmouth College</a>.</p><p>She can be reached via either of the following methods:</p><ul><li>phone at (203) 432-4265, or</li><li class=last>e–mail at <a href=mailto:kathryn.miller-jensen@yale.edu>kathryn.miller-jensen@yale.edu</a>.</li></ul></div><div><h3>Lab News</h3><ul><li class=news><a href=./news#cshl-systems-immunology-2021>Kathryn co-organizes Systems Immunology conference</a>
<time>Tuesday, Apr 20, 2021</time></li><li class=news><a href=./news#ydn-understanding-immune-systems>Yale lab observes how macrophages respond to conflicting signals</a>
<time>Sunday, Mar 21, 2021</time></li><li class=news><a href=./news#yem-cellular-chatter>Researchers Aim to Decode Communications Within a Tumor</a>
<time>Thursday, Jan 28, 2021</time></li><li class=news><a href=./news#nci-grant>Yale researchers root out latent HIV viruses</a>
<time>Monday, May 25, 2020</time></li><li class=news><a href=./news#kathryn-speaks-at-ubc>Kathryn Speaks at U of British Columbia</a>
<time>Thursday, Mar 12, 2020</time></li><li class=news><a href=./news#kathryn-speaks-at-cmu>Kathryn speaks at Pitt/CMU</a>
<time>Friday, Apr 13, 2018</time></li><li class=news><a href=./news#andres-defends>Congrats, Dr. Muñoz-Rojas!</a>
<time>Friday, Mar 23, 2018</time></li><li class=news><a href=./news#ydn-rooting-out-latency>Yale researchers root out latent HIV viruses</a>
<time>Thursday, Dec 7, 2017</time></li><li class=news><a href=./news#linda-fong-defends>Linda Fong Defends</a>
<time>Monday, Nov 20, 2017</time></li><li class=news><a href=./news#elise-awarded-peb-training-grant>Elise is awarded a PEB Training grant</a>
<time>Thursday, Jun 8, 2017</time></li><li class=news><a href=./news#amanda-nsf>Amanda is awarded the NSF fellowship</a>
<time>Tuesday, Apr 5, 2016</time></li><li class=news><a href=./news#lab-featured-in-yale-scientific>Miller-Jensen lab featured in Yale Scientific</a>
<time>Wednesday, Feb 3, 2016</time></li><li class=news><a href=./news#ydn-systems-biology>Yale researchers root out latent HIV viruses</a>
<time>Sunday, Nov 15, 2015</time></li><li class=news><a href=./news#ramesh-device-in-the-news>Ramesh's device in the news</a>
<time>Sunday, Jun 28, 2015</time></li><li class=news><a href=./news#ramesh-integrative-biology>Ramesh, Victor, and Arvind's paper is published in Integrative Biology</a>
<time>Sunday, Jun 28, 2015</time></li></ul></div><div><h3>Contact us</h3><p>Our laboratory is located in the heart of the Yale campus between old campus and Science Hill. You can reach us by phone
at (203) 432‑4265.</p><p><b>Mailing Address</b><br>P.O. Box 208260<br>New Haven, CT 06520</p><p><b>Office Address</b><br>55 Prospect Street<br>MEC 311<br>New Haven, CT 06511</p></div><div><a href="https://maps.google.com/maps?q=55+Prospect+Street,+New+Haven,+CT&hl=en&ll=41.313225,-72.925165&spn=0.009864,0.019205&sll=37.0625,-95.677068&sspn=42.445866,78.662109&oq=55+Prospect+Street&t=h&hnear=55+Prospect+St,+New+Haven,+Connecticut+06511&z=16"><img id=lab-map class="box-rotate-10 large-shadow hidden-xs hidden-sm" height=440 width=440 src=./img/map.jpg></a></div></div></main></body></html>