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implicit real*8(a-h,o-z)
c refining the clusters by using positional information/operon
parameter(ih0=21,ih=84,ifr=3)
parameter(naa=20)
parameter(llr=3,mm=4)
parameter(iigsize=12000000,nngene=12000)
dimension lend(nngene),irend(nngene)
dimension lenda(nngene),irenda(nngene)
dimension iy(iigsize),lena(nngene)
dimension icsize(nngene)
dimension iclus(nngene,nngene)
dimension k(ifr),kaa(nngene)
dimension rpos(nngene,nngene),irclus(nngene)
character sign(nngene),signa(nngene),gnome*12000000
character*100 genome_file, annotation_file
character junk
common/pvt1/ncluscodfreq(nngene,ih),
. nclusamfreq(nngene,ih),icluslen(nngene),len(nngene),
. ncodonfreq(nngene,ih),naminofreq(nngene,ih)
common/pvt2/iaa(20,6),iab(20)
c write(*,*)"Enter genome file name, annotation file name"
c read(*,*)genome_file,annotation_file
c nnc=IARGC()
c call GETARG(1,genome_file)
c call GETARG(2, annotation_file)
open(1,file='JSCB_coord')
open(2,file='JSCBinput')
open(31,file='JSCB_output.clus')
open(41,file='JSCB_output.gi')
nn=0
do i=1,nngene
read(1,*,iostat=kk)junk
if(kk/=0)exit
nn=nn+1
enddo
ngene=nn
rewind 1
read(2,*)gnome
igsize=LEN_TRIM(ADJUSTL(gnome))
rewind 2
clusthres=1.d0
thres2=0.d0
thres3=0.995d0
mingenelen=3
iaa(1,1)=42
iaa(1,2)=43
iaa(2,1)=41
iaa(2,2)=44
iaa(2,3)=58
iaa(2,4)=59
iaa(2,5)=57
iaa(2,6)=60
iaa(3,1)=26
iaa(3,2)=27
iaa(3,3)=25
iaa(4,1)=28
iaa(5,1)=74
iaa(5,2)=75
iaa(5,3)=73
iaa(5,4)=76
iaa(6,1)=46
iaa(6,2)=47
iaa(6,3)=45
iaa(6,4)=48
iaa(6,5)=34
iaa(6,6)=35
iaa(7,1)=62
iaa(7,2)=63
iaa(7,3)=61
iaa(7,4)=64
iaa(8,1)=30
iaa(8,2)=31
iaa(8,3)=29
iaa(8,4)=32
iaa(9,1)=78
iaa(9,2)=79
iaa(9,3)=77
iaa(9,4)=80
iaa(10,1)=38
iaa(10,2)=39
iaa(11,1)=54
iaa(11,2)=55
iaa(12,1)=53
iaa(12,2)=56
iaa(13,1)=22
iaa(13,2)=23
iaa(14,1)=21
iaa(14,2)=24
iaa(15,1)=70
iaa(15,2)=71
iaa(16,1)=69
iaa(16,2)=72
iaa(17,1)=50
iaa(17,2)=51
iaa(18,1)=52
iaa(19,1)=66
iaa(19,2)=67
iaa(19,3)=65
iaa(19,4)=68
iaa(19,5)=33
iaa(19,6)=36
iaa(20,1)=82
iaa(20,2)=83
iaa(20,3)=81
iaa(20,4)=84
iab(1)=2
iab(2)=6
iab(3)=3
iab(4)=1
iab(5)=4
iab(6)=6
iab(7)=4
iab(8)=4
iab(9)=4
iab(10)=2
iab(11)=2
iab(12)=2
iab(13)=2
iab(14)=2
iab(15)=2
iab(16)=2
iab(17)=2
iab(18)=1
iab(19)=6
iab(20)=4
ngenea=0
do ks=1,ngene
read(1,*)signa(ks),lenda(ks),irenda(ks)
lena(ks)=irenda(ks)-lenda(ks)-2
if(mod(lena(ks),3).ne.0)then
print*,ks,lena(ks)
pause
endif
if(lena(ks)-3.gt.mingenelen)then
ngenea=ngenea+1
sign(ngenea)=signa(ks)
lend(ngenea)=lenda(ks)
irend(ngenea)=irenda(ks)
len(ngenea)=lena(ks)
endif
enddo
thres=.8d0
do i=1,ngenea
do j=ih0,ih
ncodonfreq(i,j)=1
naminofreq(i,j)=0
enddo
enddo
nnp=0
do ii=1,igsize
if(gnome(ii:ii).eq.'A')then
iy(ii)=1
elseif(gnome(ii:ii).eq.'T')then
iy(ii)=2
elseif(gnome(ii:ii).eq.'C')then
iy(ii)=3
elseif(gnome(ii:ii).eq.'G')then
iy(ii)=4
else
nnp=nnp+1
c print*,ii,gnome(ii:ii),iy(ii)
pause 'problem with genome file'
endif
enddo
c print*,nnp
c pause
do j=1,ngenea
len(j)=irend(j)-lend(j)-2
if(sign(j).eq.'+')then
do ii=1,(irend(j)-lend(j)-2)/3
do ir=1,ifr
k(ir)=iy(lend(j)+ii*ifr-(ifr-ir)-1)
enddo
lx=0
do ir=1,ifr
lx=lx+mm**(llr-ir)*k(ir)
enddo
ncodonfreq(j,lx)=ncodonfreq(j,lx)+1
enddo
do ii=ih0,ih
do nff=1,naa
do nff2=1,iab(nff)
if(iaa(nff,nff2).eq.ii)then
do nff3=1,iab(nff)
nff4=iaa(nff,nff3)
naminofreq(j,ii)=naminofreq(j,ii)+ncodonfreq(j,nff4)
enddo
goto 764
endif
enddo
enddo
764 enddo
elseif(sign(j).eq.'-')then
do ii=1,(irend(j)-lend(j)-2)/3
do ir=1,ifr
if(iy(irend(j)-ii*ifr+(ifr-ir)+1).eq.1)then
k(ir)=2
elseif(iy(irend(j)-ii*ifr+(ifr-ir)+1).eq.2)then
k(ir)=1
elseif(iy(irend(j)-ii*ifr+(ifr-ir)+1).eq.3)then
k(ir)=4
elseif(iy(irend(j)-ii*ifr+(ifr-ir)+1).eq.4)then
k(ir)=3
endif
enddo
lx=0
do ir=1,ifr
lx=lx+mm**(llr-ir)*k(ir)
enddo
ncodonfreq(j,lx)=ncodonfreq(j,lx)+1
enddo
do ii=ih0,ih
do nff=1,naa
do nff2=1,iab(nff)
if(iaa(nff,nff2).eq.ii)then
do nff3=1,iab(nff)
nff4=iaa(nff,nff3)
naminofreq(j,ii)=naminofreq(j,ii)+ncodonfreq(j,nff4)
enddo
goto 765
endif
enddo
enddo
765 enddo
endif
enddo
numgene=1
nclus=1
52 icsize(nclus)=1
iclus(nclus,icsize(nclus))=numgene
do nff2=ih0,ih
ncluscodfreq(nclus,nff2)=0
nclusamfreq(nclus,nff2)=0
enddo
do nff2=ih0,ih
do nff=1,icsize(nclus)
ncluscodfreq(nclus,nff2)=ncluscodfreq(nclus,nff2)
. +ncodonfreq(iclus(nclus,nff),nff2)
enddo
enddo
do nff2=ih0,ih
do nff=1,icsize(nclus)
nclusamfreq(nclus,nff2)=nclusamfreq(nclus,nff2)
. +naminofreq(iclus(nclus,nff),nff2)
enddo
enddo
if(numgene.eq.ngenea)then
nclus0=nclus
write(99,*)'nclus0',nclus0
goto 50
endif
51 icluslen(nclus)=0
do ii=1,naa
icluslen(nclus)=icluslen(nclus)+nclusamfreq(nclus,iaa(ii,1))
enddo
numgene=numgene+1
lengtot=icluslen(nclus)+len(numgene)/3
rnn=lengtot
ddiv=divgn2(numgene,nclus,lengtot)
pbc=sig(rnn,abs(ddiv))
if(pbc.lt.thres)then
do nff2=ih0,ih
ncluscodfreq(nclus,nff2)=ncluscodfreq(nclus,nff2)+
. ncodonfreq(numgene,nff2)
nclusamfreq(nclus,nff2)=nclusamfreq(nclus,nff2)+
. naminofreq(numgene,nff2)
enddo
icsize(nclus)=icsize(nclus)+1
iclus(nclus,icsize(nclus))=numgene
if(numgene.eq.ngenea)then
nclus0=nclus
write(99,*)'nclus0',nclus0
goto 50
endif
goto 51
else
nclus=nclus+1
goto 52
endif
50 do i=1,nclus
icluslen(i)=0
enddo
do i=1,nclus
do ii=1,naa
icluslen(i)=icluslen(i)+nclusamfreq(i,iaa(ii,1))
enddo
enddo
do kkn1=1,nclus-1
do kkn2=kkn1+1,nclus
lengtot=icluslen(kkn1)+icluslen(kkn2)
djs=divgn(kkn1,kkn2,lengtot)
rnn=icluslen(kkn1)+icluslen(kkn2)
pbc=sig(rnn,djs)
if(pbc.lt.thres3)then
do nff2=ih0,ih
ncluscodfreq(kkn1,nff2)=ncluscodfreq(kkn1,nff2)+
. ncluscodfreq(kkn2,nff2)
nclusamfreq(kkn1,nff2)=nclusamfreq(kkn1,nff2)+
. nclusamfreq(kkn2,nff2)
enddo
do i=1,icsize(kkn2)
iclus(kkn1,icsize(kkn1)+i)=iclus(kkn2,i)
enddo
icsize(kkn1)=icsize(kkn1)+icsize(kkn2)
do i=kkn2,nclus-1
do j=1,icsize(i+1)
iclus(i,j)=iclus(i+1,j)
enddo
enddo
do i=kkn2,nclus-1
icsize(i)=icsize(i+1)
do j=ih0,ih
ncluscodfreq(i,j)=ncluscodfreq(i+1,j)
nclusamfreq(i,j)=nclusamfreq(i+1,j)
enddo
enddo
nclus=nclus-1
goto 50
endif
enddo
enddo
59 do i=1,nclus
do j=1,nclus
rpos(i,j)=0.d0
enddo
enddo
do i=1,nclus
do j=1,icsize(i)
do ii=1,nclus
do jj=1,icsize(ii)
if(iclus(i,j)-1.eq.iclus(ii,jj))then
do iii=1,nclus
do jjj=1,icsize(iii)
if(iclus(i,j)+1.eq.iclus(iii,jjj))then
if(ii.eq.iii)then
rpos(i,ii)=rpos(i,ii)+1.d0
goto 779
endif
endif
enddo
enddo
endif
enddo
enddo
779 enddo
enddo
996 do i=1,nclus-1
do j=i+1,nclus
c rp=(rpos(i,j)/(icsize(i)-rpos(i,i))+
c . rpos(j,i)/(icsize(j)-rpos(j,j)))/2.d0
rp=(rpos(i,j)/icsize(i)+
. rpos(j,i)/icsize(j))/2.d0
if(rp.gt.clusthres)then
do nff2=ih0,ih
ncluscodfreq(i,nff2)=ncluscodfreq(i,nff2)+
. ncluscodfreq(j,nff2)
nclusamfreq(i,nff2)=nclusamfreq(i,nff2)+
. nclusamfreq(j,nff2)
enddo
do m=1,icsize(j)
iclus(i,icsize(i)+m)=iclus(j,m)
enddo
icsize(i)=icsize(i)+icsize(j)
do iu=j,nclus-1
do ju=1,icsize(iu+1)
iclus(iu,ju)=iclus(iu+1,ju)
enddo
enddo
do iu=j,nclus-1
icsize(iu)=icsize(iu+1)
do ju=ih0,ih
ncluscodfreq(iu,ju)=ncluscodfreq(iu+1,ju)
nclusamfreq(iu,ju)=nclusamfreq(iu+1,ju)
enddo
enddo
nclus=nclus-1
do mi=1,nclus
do mj=1,nclus
rpos(mi,mj)=0.d0
enddo
enddo
do mi=1,nclus
do mj=1,icsize(mi)
do ii=1,nclus
do jj=1,icsize(ii)
if(iclus(mi,mj)-1.eq.iclus(ii,jj))then
do iii=1,nclus
do jjj=1,icsize(iii)
if(iclus(mi,mj)+1.eq.iclus(iii,jjj))then
if(ii.eq.iii)then
rpos(mi,ii)=rpos(mi,ii)+1.d0
goto 778
endif
endif
enddo
enddo
endif
enddo
enddo
778 enddo
enddo
goto 996
endif
enddo
enddo
do i=1,nclus
icluslen(i)=0
enddo
do i=1,nclus
do ii=1,naa
icluslen(i)=icluslen(i)+nclusamfreq(i,iaa(ii,1))
enddo
enddo
nnh=0
nnm=0
do i=1,nclus
kw=0
do j=1,icsize(i)
jfk=0
do ii=1,nclus
do jj=1,icsize(ii)
if(iclus(i,j).eq.1.or.iclus(i,j).eq.ngenea)goto 299
if(iclus(i,j)-1.eq.iclus(ii,jj))then
mgg1=ii
jfk=jfk+1
elseif(iclus(i,j)+1.eq.iclus(ii,jj))then
mgg2=ii
jfk=jfk+1
endif
if(jfk.eq.2)goto 29
enddo
enddo
29 if(mgg1.eq.mgg2.and.mgg1.ne.i)then
nnh=nnh+1
lengtot=len(iclus(i,j))/3+icluslen(mgg1)
gdjs=divgn2(iclus(i,j),mgg1,lengtot)
rnn=lengtot
pbc=sig(rnn,gdjs)
c if(pbc.lt.thres)then
if(pbc.lt.thres2)then
nnm=nnm+1
kw=kw+1
icsize(mgg1)=icsize(mgg1)+1
iclus(mgg1,icsize(mgg1))=iclus(i,j)
icluslen(mgg1)=icluslen(mgg1)+len(iclus(i,j))/3
do nff2=ih0,ih
ncluscodfreq(mgg1,nff2)=ncluscodfreq(mgg1,nff2)+
. ncodonfreq(iclus(i,j),nff2)
nclusamfreq(mgg1,nff2)=nclusamfreq(mgg1,nff2)+
. naminofreq(iclus(i,j),nff2)
enddo
kaa(kw)=j
endif
endif
299 enddo
kdd=0
do ii=1,icsize(i)
do jj=1,kw
if(ii.eq.kaa(jj))goto 399
enddo
kdd=kdd+1
irclus(kdd)=iclus(i,ii)
399 enddo
icsize(i)=kdd
do ii=1,kdd
iclus(i,ii)=irclus(ii)
enddo
do nff2=ih0,ih
ncluscodfreq(i,nff2)=0
nclusamfreq(i,nff2)=0
enddo
do nff2=ih0,ih
do nff=1,icsize(i)
ncluscodfreq(i,nff2)=ncluscodfreq(i,nff2)
. +ncodonfreq(iclus(i,nff),nff2)
enddo
enddo
do nff2=ih0,ih
do nff=1,icsize(i)
nclusamfreq(i,nff2)=nclusamfreq(i,nff2)
. +naminofreq(iclus(i,nff),nff2)
enddo
enddo
icluslen(i)=0
do ii=1,naa
icluslen(i)=icluslen(i)+nclusamfreq(i,iaa(ii,1))
enddo
enddo
do i=1,nclus
do j=1,icsize(i)
do m=1,ngene
if(lenda(m).eq.lend(iclus(i,j)).and.irenda(m)
. .eq.irend(iclus(i,j)))then
write(31,*)i,icsize(i),m,lena(m)
endif
enddo
enddo
enddo
do m=1,ngene
do i=1,nclus
do j=1,icsize(i)
if(lenda(m).eq.lend(iclus(i,j)).and.irenda(m)
. .eq.irend(iclus(i,j)))then
write(41,*)m,i,icsize(i),lena(m)
endif
enddo
enddo
enddo
end
FUNCTION rentrotot(id1,id2,lengtot)
implicit real*8(a-h,o-z)
parameter(nngene=12000)
parameter(ih0=21,ih=84,naa=20)
common/pvt1/ncluscodfreq(nngene,ih),
. nclusamfreq(nngene,ih),icluslen(nngene),len(nngene),
. ncodonfreq(nngene,ih),naminofreq(nngene,ih)
common/pvt2/iaa(20,6),iab(20)
rentrotot=0.d0
do nff=1,naa
rentroi=0.d0
do nff2=1,iab(nff)
pp=(ncluscodfreq(id1,iaa(nff,nff2))+
. ncluscodfreq(id2,iaa(nff,nff2)))/dfloat
. (nclusamfreq(id1,iaa(nff,1))+nclusamfreq(id2,iaa(nff,1)))
rentroi=rentroi+pp*log(pp)
enddo
pp0=(nclusamfreq(id1,iaa(nff,1))+nclusamfreq(id2,iaa(nff,1)))/
. dfloat(lengtot)
rentroi=rentroi*pp0
rentrotot=rentrotot+rentroi
enddo
rentrotot=-rentrotot
return
end
FUNCTION rentrotot2(id1,id2,lengtot)
implicit real*8(a-h,o-z)
parameter(nngene=12000)
parameter(ih0=21,ih=84,naa=20)
common/pvt1/ncluscodfreq(nngene,ih),
. nclusamfreq(nngene,ih),icluslen(nngene),len(nngene),
. ncodonfreq(nngene,ih),naminofreq(nngene,ih)
common/pvt2/iaa(20,6),iab(20)
rentrotot2=0.d0
do nff=1,naa
rentroi=0.d0
do nff2=1,iab(nff)
pp=(ncodonfreq(id1,iaa(nff,nff2))+
. ncluscodfreq(id2,iaa(nff,nff2)))/dfloat
. (naminofreq(id1,iaa(nff,1))+nclusamfreq(id2,iaa(nff,1)))
rentroi=rentroi+pp*log(pp)
enddo
pp0=(naminofreq(id1,iaa(nff,1))+nclusamfreq(id2,iaa(nff,1)))/
. dfloat(lengtot)
rentroi=rentroi*pp0
rentrotot2=rentrotot2+rentroi
enddo
rentrotot2=-rentrotot2
return
end
FUNCTION rentro(id)
implicit real*8(a-h,o-z)
parameter(nngene=12000)
parameter(ih0=21,ih=84,naa=20)
common/pvt1/ncluscodfreq(nngene,ih),
. nclusamfreq(nngene,ih),icluslen(nngene),len(nngene),
. ncodonfreq(nngene,ih),naminofreq(nngene,ih)
common/pvt2/iaa(20,6),iab(20)
rentro=0.d0
do nff=1,naa
rentroi=0.d0
do nff2=1,iab(nff)
pp=ncluscodfreq(id,iaa(nff,nff2))/
. dfloat(nclusamfreq(id,iaa(nff,nff2)))
rentroi=rentroi+pp*log(pp)
enddo
rentroi=rentroi*(nclusamfreq(id,iaa(nff,1))/dfloat(icluslen(id)))
rentro=rentro+rentroi
enddo
rentro=-rentro
return
end
FUNCTION rentro2(id)
implicit real*8(a-h,o-z)
parameter(nngene=12000)
parameter(ih0=21,ih=84,naa=20)
common/pvt1/ncluscodfreq(nngene,ih),
. nclusamfreq(nngene,ih),icluslen(nngene),len(nngene),
. ncodonfreq(nngene,ih),naminofreq(nngene,ih)
common/pvt2/iaa(20,6),iab(20)
rentro2=0.d0
do nff=1,naa
rentroi=0.d0
do nff2=1,iab(nff)
pp=ncodonfreq(id,iaa(nff,nff2))/
. dfloat(naminofreq(id,iaa(nff,nff2)))
rentroi=rentroi+pp*log(pp)
enddo
rentroi=rentroi*(naminofreq(id,iaa(nff,1))/dfloat(len(id)/3))
rentro2=rentro2+rentroi
enddo
rentro2=-rentro2
return
end
FUNCTION divgn(i,j,lengtot)
implicit real*8(a-h,o-z)
parameter(nngene=12000)
parameter(ih0=21,ih=84)
common/pvt1/ncluscodfreq(nngene,ih),
. nclusamfreq(nngene,ih),icluslen(nngene),len(nngene),
. ncodonfreq(nngene,ih),naminofreq(nngene,ih)
hhh=2.0d0
xxx=1/log(hhh)
divgn=xxx*(rentrotot(i,j,lengtot)-
. (icluslen(i)*rentro(i)+icluslen(j)*rentro(j))/
. dfloat(lengtot))
return
end
FUNCTION divgn2(i,j,lengtot)
implicit real*8(a-h,o-z)
parameter(nngene=12000)
parameter(ih0=21,ih=84)
common/pvt1/ncluscodfreq(nngene,ih),
. nclusamfreq(nngene,ih),icluslen(nngene),len(nngene),
. ncodonfreq(nngene,ih),naminofreq(nngene,ih)
hhh=2.0d0
xxx=1/log(hhh)
divgn2=xxx*(rentrotot2(i,j,lengtot)-
. ((len(i)/3)*rentro2(i)+icluslen(j)*rentro(j))/
. dfloat(lengtot))
return
end
FUNCTION sig(rnn,djsmx)
implicit real*8(a-h,o-z)
snn=rnn*log(2.d0)*djsmx
sig=gammp(30.d0,snn)
return
end
FUNCTION gammp(a,x)
REAL*8 a,gammp,x
C USES gcf,gser
REAL*8 gammcf,gamser,gln
if(x.lt.0..or.a.le.0.) then
c write(101,*)a,x
pause 'bad arguments in gammp'
endif
if(x.lt.a+1.)then
call gser(gamser,a,x,gln)
gammp=gamser
else
call gcf(gammcf,a,x,gln)
gammp=1.-gammcf
endif
return
END
SUBROUTINE gser(gamser,a,x,gln)
INTEGER ITMAX
REAL*8 a,gamser,gln,x,EPS
PARAMETER (ITMAX=9000,EPS=3.e-7)
C USES gammln
INTEGER n
REAL*8 ap,del,sum,gammln
gln=gammln(a)
if(x.le.0.)then
if(x.lt.0.)pause 'x < 0 in gser'
gamser=0.
return
endif
ap=a
sum=1./a
del=sum
do 11 n=1,ITMAX
ap=ap+1.
del=del*x/ap
sum=sum+del
if(abs(del).lt.abs(sum)*EPS)goto 1
11 continue
pause 'a too large, ITMAX too small in gser'
1 gamser=sum*exp(-x+a*log(x)-gln)
return
END
SUBROUTINE gcf(gammcf,a,x,gln)
INTEGER ITMAX
REAL*8 a,gammcf,gln,x,EPS,FPMIN
PARAMETER (ITMAX=9000,EPS=3.e-7,FPMIN=1.e-30)
C USES gammln
INTEGER i
REAL*8 an,b,c,d,del,h,gammln
gln=gammln(a)
b=x+1.-a
c=1./FPMIN
d=1./b
h=d
do 11 i=1,ITMAX
an=-i*(i-a)
b=b+2.
d=an*d+b
if(abs(d).lt.FPMIN)d=FPMIN
c=b+an/c
if(abs(c).lt.FPMIN)c=FPMIN
d=1./d
del=d*c
h=h*del
if(abs(del-1.).lt.EPS)goto 1
11 continue
pause 'a too large, ITMAX too small in gcf'
1 gammcf=exp(-x+a*log(x)-gln)*h
return
END
FUNCTION gammln(xx)
REAL*8 gammln,xx
INTEGER j
DOUBLE PRECISION ser,stp,tmp,x,y,cof(6)
SAVE cof,stp
DATA cof,stp/76.18009172947146d0,-86.50532032941677d0,
*24.01409824083091d0,-1.231739572450155d0,.1208650973866179d-2,
*-.5395239384953d-5,2.5066282623310005d0/
x=xx
y=x
tmp=x+5.5d0
tmp=(x+0.5d0)*log(tmp)-tmp
ser=1.000000000190015d0
do 11 j=1,6
y=y+1.d0
ser=ser+cof(j)/y
11 continue
gammln=tmp+log(stp*ser/x)
return
END
FUNCTION ran3a(nth,id,idum)
INTEGER idum,id,nth
INTEGER MBIG,MSEED,MZ,ik,nthres
C REAL MBIG,MSEED,MZ
REAL ran3a,FAC
PARAMETER (MBIG=1000000000,MSEED=161803398,MZ=0,FAC=1./MBIG)
C PARAMETER (MBIG=4000000.,MSEED=1618033.,MZ=0.,FAC=1./MBIG)
PARAMETER (nthres=20,ik=20)
INTEGER i,iff(nthres,ik),ii,inext(nthres,ik),inextp(nthres,ik),k
INTEGER mj,mk,ma(nthres,ik,55)
C REAL mj,mk,ma(55)
SAVE iff,inext,inextp,ma
DATA iff / 400*0 /
if(idum.lt.0.or.iff(nth,id).eq.0)then
iff(nth,id)=1
mj=MSEED-iabs(idum)
mj=mod(mj,MBIG)
ma(nth,id,55)=mj
mk=1
do 11 i=1,54
ii=mod(21*i,55)
ma(nth,id,ii)=mk
mk=mj-mk
if(mk.lt.MZ)mk=mk+MBIG
mj=ma(nth,id,ii)
11 continue
do 13 k=1,4
do 12 i=1,55
ma(nth,id,i)=ma(nth,id,i)-ma(nth,id,1+mod(i+30,55))
if(ma(nth,id,i).lt.MZ)ma(nth,id,i)=ma(nth,id,i)+MBIG
12 continue
13 continue
inext(nth,id)=0
inextp(nth,id)=31
idum=1
endif
inext(nth,id)=inext(nth,id)+1
if(inext(nth,id).eq.56)inext(nth,id)=1
inextp(nth,id)=inextp(nth,id)+1
if(inextp(nth,id).eq.56)inextp(nth,id)=1
mj=ma(nth,id,inext(nth,id))-ma(nth,id,inextp(nth,id))
if(mj.lt.MZ)mj=mj+MBIG
ma(nth,id,inext(nth,id))=mj
ran3a=mj*FAC
return
END
FUNCTION ran3b(nth,id,idum)
INTEGER nth,idum,id
INTEGER MBIG,MSEED,MZ,ik,nthres
C REAL MBIG,MSEED,MZ
REAL ran3b,FAC
PARAMETER (MBIG=1000000000,MSEED=161803398,MZ=0,FAC=1./MBIG)
C PARAMETER (MBIG=4000000.,MSEED=1618033.,MZ=0.,FAC=1./MBIG)
PARAMETER (nthres=20,ik=20)
INTEGER i,iff(nthres,ik),ii,inext(nthres,ik),inextp(nthres,ik),k
INTEGER mj,mk,ma(nthres,ik,55)
C REAL mj,mk,ma(55)
SAVE iff,inext,inextp,ma
DATA iff / 400*0 /
if(idum.lt.0.or.iff(nth,id).eq.0)then
iff(nth,id)=1
mj=MSEED-iabs(idum)
mj=mod(mj,MBIG)
ma(nth,id,55)=mj
mk=1
do 11 i=1,54
ii=mod(21*i,55)
ma(nth,id,ii)=mk
mk=mj-mk
if(mk.lt.MZ)mk=mk+MBIG
mj=ma(nth,id,ii)
11 continue
do 13 k=1,4
do 12 i=1,55
ma(nth,id,i)=ma(nth,id,i)-ma(nth,id,1+mod(i+30,55))
if(ma(nth,id,i).lt.MZ)ma(nth,id,i)=ma(nth,id,i)+MBIG
12 continue
13 continue
inext(nth,id)=0
inextp(nth,id)=31
idum=1
endif
inext(nth,id)=inext(nth,id)+1
if(inext(nth,id).eq.56)inext(nth,id)=1
inextp(nth,id)=inextp(nth,id)+1
if(inextp(nth,id).eq.56)inextp(nth,id)=1
mj=ma(nth,id,inext(nth,id))-ma(nth,id,inextp(nth,id))
if(mj.lt.MZ)mj=mj+MBIG
ma(nth,id,inext(nth,id))=mj
ran3b=mj*FAC
return
END
SUBROUTINE sort(n,arr)
INTEGER n,M,NSTACK
REAL*8 arr(n)
PARAMETER (M=7,NSTACK=500)
INTEGER i,ir,j,jstack,k,l,istack(NSTACK)
REAL*8 a,temp
jstack=0
l=1
ir=n
1 if(ir-l.lt.M)then
do 12 j=l+1,ir
a=arr(j)
do 11 i=j-1,1,-1
if(arr(i).le.a)goto 2
arr(i+1)=arr(i)
11 continue
i=0
2 arr(i+1)=a
12 continue
if(jstack.eq.0)return
ir=istack(jstack)
l=istack(jstack-1)
jstack=jstack-2
else
k=(l+ir)/2
temp=arr(k)
arr(k)=arr(l+1)
arr(l+1)=temp
if(arr(l+1).gt.arr(ir))then
temp=arr(l+1)
arr(l+1)=arr(ir)
arr(ir)=temp
endif
if(arr(l).gt.arr(ir))then
temp=arr(l)
arr(l)=arr(ir)
arr(ir)=temp
endif
if(arr(l+1).gt.arr(l))then
temp=arr(l+1)
arr(l+1)=arr(l)
arr(l)=temp
endif
i=l+1
j=ir
a=arr(l)
3 continue
i=i+1
if(arr(i).lt.a)goto 3
4 continue
j=j-1
if(arr(j).gt.a)goto 4
if(j.lt.i)goto 5
temp=arr(i)
arr(i)=arr(j)
arr(j)=temp
goto 3
5 arr(l)=arr(j)
arr(j)=a
jstack=jstack+2
if(jstack.gt.NSTACK)pause 'NSTACK too small in sort'
if(ir-i+1.ge.j-l)then
istack(jstack)=ir
istack(jstack-1)=i
ir=j-1
else
istack(jstack)=j-1
istack(jstack-1)=l
l=i
endif
endif
goto 1
END