diff --git a/lib/block-supports/layout.php b/lib/block-supports/layout.php
index fa63beef0710b3..466c8a9cf159d1 100644
--- a/lib/block-supports/layout.php
+++ b/lib/block-supports/layout.php
@@ -54,7 +54,7 @@ function gutenberg_get_layout_style( $selector, $layout, $has_block_gap_support
 		$wide_max_width_value = wp_strip_all_tags( explode( ';', $wide_max_width_value )[0] );
 
 		if ( $content_size || $wide_size ) {
-			$style  = "$selector > :where(:not(.alignleft):not(.alignright)) {";
+			$style  = "$selector > :where(:not(.alignleft):not(.alignright):not(.alignfull)) {";
 			$style .= 'max-width: ' . esc_html( $all_max_width_value ) . ';';
 			$style .= 'margin-left: auto !important;';
 			$style .= 'margin-right: auto !important;';
diff --git a/packages/block-editor/src/layouts/flow.js b/packages/block-editor/src/layouts/flow.js
index 1d8ea7d7a6aea2..d267fd609f2447 100644
--- a/packages/block-editor/src/layouts/flow.js
+++ b/packages/block-editor/src/layouts/flow.js
@@ -132,7 +132,7 @@ export default {
 				? `
 					${ appendSelectors(
 						selector,
-						'> :where(:not(.alignleft):not(.alignright))'
+						'> :where(:not(.alignleft):not(.alignright):not(.alignfull))'
 					) } {
 						max-width: ${ contentSize ?? wideSize };
 						margin-left: auto !important;