diff --git a/framework b/framework
index 423e41ec8044..29e8dce54a10 160000
--- a/framework
+++ b/framework
@@ -1 +1 @@
-Subproject commit 423e41ec8044a797eca7ac3a36497963fc4e5606
+Subproject commit 29e8dce54a1041e22489f713cc8c44f700fafcec
diff --git a/scripts/config.py b/scripts/config.py
index c53f9e7fe200..8704bdb51ea3 100755
--- a/scripts/config.py
+++ b/scripts/config.py
@@ -396,6 +396,7 @@ def __init__(self, filename=None):
                                 self.default_path)
         super().__init__()
         self.filename = filename
+        self.inclusion_guard = None
         self.current_section = 'header'
         with open(filename, 'r', encoding='utf-8') as file:
             self.templates = [self._parse_line(line) for line in file]
@@ -413,9 +414,11 @@ def set(self, name, value=None):
                            r'(?P<arguments>(?:\((?:\w|\s|,)*\))?)' +
                            r'(?P<separator>\s*)' +
                            r'(?P<value>.*)')
+    _ifndef_line_regexp = r'#ifndef (?P<inclusion_guard>\w+)'
     _section_line_regexp = (r'\s*/?\*+\s*[\\@]name\s+SECTION:\s*' +
                             r'(?P<section>.*)[ */]*')
     _config_line_regexp = re.compile(r'|'.join([_define_line_regexp,
+                                                _ifndef_line_regexp,
                                                 _section_line_regexp]))
     def _parse_line(self, line):
         """Parse a line in mbedtls_config.h and return the corresponding template."""
@@ -426,10 +429,16 @@ def _parse_line(self, line):
         elif m.group('section'):
             self.current_section = m.group('section')
             return line
+        elif m.group('inclusion_guard') and self.inclusion_guard is None:
+            self.inclusion_guard = m.group('inclusion_guard')
+            return line
         else:
             active = not m.group('commented_out')
             name = m.group('name')
             value = m.group('value')
+            if name == self.inclusion_guard and value == '':
+                # The file double-inclusion guard is not an option.
+                return line
             template = (name,
                         m.group('indentation'),
                         m.group('define') + name +
diff --git a/scripts/make_generated_files.bat b/scripts/make_generated_files.bat
index f04f6b72a996..b03bce2ade5d 100644
--- a/scripts/make_generated_files.bat
+++ b/scripts/make_generated_files.bat
@@ -11,6 +11,7 @@ python scripts\generate_ssl_debug_helpers.py || exit /b 1
 perl scripts\generate_visualc_files.pl || exit /b 1
 python scripts\generate_psa_constants.py || exit /b 1
 python framework\scripts\generate_bignum_tests.py || exit /b 1
+python framework\scripts\generate_config_tests.py || exit /b 1
 python framework\scripts\generate_ecp_tests.py || exit /b 1
 python framework\scripts\generate_psa_tests.py || exit /b 1
 python framework\scripts\generate_test_keys.py --output tests\src\test_keys.h || exit /b 1
diff --git a/tests/.gitignore b/tests/.gitignore
index 838ea699fc53..870fa79808c9 100644
--- a/tests/.gitignore
+++ b/tests/.gitignore
@@ -3,22 +3,24 @@
 
 *.log
 /test_suite*
-data_files/mpi_write
-data_files/hmac_drbg_seed
-data_files/ctr_drbg_seed
-data_files/entropy_seed
+/data_files/mpi_write
+/data_files/hmac_drbg_seed
+/data_files/ctr_drbg_seed
+/data_files/entropy_seed
 
-include/alt-extra/psa/crypto_platform_alt.h
-include/alt-extra/psa/crypto_struct_alt.h
-include/test/instrument_record_status.h
+/include/alt-extra/psa/crypto_platform_alt.h
+/include/alt-extra/psa/crypto_struct_alt.h
+/include/test/instrument_record_status.h
 
-src/libmbed*
+/src/libmbed*
 
-libtestdriver1/*
+/libtestdriver1/*
 
 ###START_GENERATED_FILES###
 # Generated source files
 /suites/*.generated.data
+/suites/test_suite_config.mbedtls_boolean.data
+/suites/test_suite_config.psa_boolean.data
 /suites/test_suite_psa_crypto_storage_format.v[0-9]*.data
 /suites/test_suite_psa_crypto_storage_format.current.data
 /src/test_keys.h
diff --git a/tests/CMakeLists.txt b/tests/CMakeLists.txt
index 62be14e5339b..213578d370ee 100644
--- a/tests/CMakeLists.txt
+++ b/tests/CMakeLists.txt
@@ -30,6 +30,18 @@ execute_process(
 string(REGEX REPLACE "[^;]*/" ""
        base_bignum_generated_data_files "${base_bignum_generated_data_files}")
 
+execute_process(
+    COMMAND
+        ${MBEDTLS_PYTHON_EXECUTABLE}
+        ${CMAKE_CURRENT_SOURCE_DIR}/../framework/scripts/generate_config_tests.py
+        --list-for-cmake
+    WORKING_DIRECTORY
+        ${CMAKE_CURRENT_SOURCE_DIR}/..
+    OUTPUT_VARIABLE
+        base_config_generated_data_files)
+string(REGEX REPLACE "[^;]*/" ""
+       base_config_generated_data_files "${base_config_generated_data_files}")
+
 execute_process(
     COMMAND
         ${MBEDTLS_PYTHON_EXECUTABLE}
@@ -61,11 +73,15 @@ set(base_generated_data_files
 string(REGEX REPLACE "([^;]+)" "suites/\\1"
        all_generated_data_files "${base_generated_data_files}")
 set(bignum_generated_data_files "")
+set(config_generated_data_files "")
 set(ecp_generated_data_files "")
 set(psa_generated_data_files "")
 foreach(file ${base_bignum_generated_data_files})
     list(APPEND bignum_generated_data_files ${CMAKE_CURRENT_BINARY_DIR}/suites/${file})
 endforeach()
+foreach(file ${base_config_generated_data_files})
+    list(APPEND config_generated_data_files ${CMAKE_CURRENT_BINARY_DIR}/suites/${file})
+endforeach()
 foreach(file ${base_ecp_generated_data_files})
     list(APPEND ecp_generated_data_files ${CMAKE_CURRENT_BINARY_DIR}/suites/${file})
 endforeach()
@@ -92,6 +108,21 @@ if(GEN_FILES)
             ${CMAKE_CURRENT_SOURCE_DIR}/../framework/scripts/mbedtls_framework/test_case.py
             ${CMAKE_CURRENT_SOURCE_DIR}/../framework/scripts/mbedtls_framework/test_data_generation.py
     )
+    add_custom_command(
+        OUTPUT
+            ${config_generated_data_files}
+        WORKING_DIRECTORY
+            ${CMAKE_CURRENT_SOURCE_DIR}/..
+        COMMAND
+            ${MBEDTLS_PYTHON_EXECUTABLE}
+            ${CMAKE_CURRENT_SOURCE_DIR}/../framework/scripts/generate_config_tests.py
+            --directory ${CMAKE_CURRENT_BINARY_DIR}/suites
+        DEPENDS
+            ${CMAKE_CURRENT_SOURCE_DIR}/../framework/scripts/generate_config_tests.py
+            # Do not declare the configuration files as dependencies: they
+            # change too often in ways that don't affect the result
+            # ((un)commenting some options).
+    )
     add_custom_command(
         OUTPUT
             ${ecp_generated_data_files}
@@ -142,6 +173,7 @@ endif()
 # With this line, only 4 sub-makefiles include the above command, that reduces
 # the risk of a race.
 add_custom_target(test_suite_bignum_generated_data DEPENDS ${bignum_generated_data_files})
+add_custom_target(test_suite_config_generated_data DEPENDS ${config_generated_data_files})
 add_custom_target(test_suite_ecp_generated_data DEPENDS ${ecp_generated_data_files})
 add_custom_target(test_suite_psa_generated_data DEPENDS ${psa_generated_data_files})
 # If SKIP_TEST_SUITES is not defined with -D, get it from the environment.
@@ -199,6 +231,10 @@ function(add_test_suite suite_name)
         set(data_file
             ${CMAKE_CURRENT_BINARY_DIR}/suites/test_suite_${data_name}.data)
         set(dependency test_suite_bignum_generated_data)
+    elseif(";${config_generated_data_names};" MATCHES ";${data_name};")
+        set(data_file
+            ${CMAKE_CURRENT_BINARY_DIR}/suites/test_suite_${data_name}.data)
+        set(dependency test_suite_bignum_generated_data)
     elseif(";${ecp_generated_data_names};" MATCHES ";${data_name};")
         set(data_file
             ${CMAKE_CURRENT_BINARY_DIR}/suites/test_suite_${data_name}.data)
@@ -210,7 +246,11 @@ function(add_test_suite suite_name)
     else()
         set(data_file
             ${CMAKE_CURRENT_SOURCE_DIR}/suites/test_suite_${data_name}.data)
-        set(dependency test_suite_bignum_generated_data test_suite_ecp_generated_data test_suite_psa_generated_data)
+        set(dependency
+            test_suite_bignum_generated_data
+            test_suite_config_generated_data
+            test_suite_ecp_generated_data
+            test_suite_psa_generated_data)
     endif()
 
     add_custom_command(
diff --git a/tests/Makefile b/tests/Makefile
index 7ab4d9c47469..f1ca60472d53 100644
--- a/tests/Makefile
+++ b/tests/Makefile
@@ -17,7 +17,6 @@ ifdef RECORD_PSA_STATUS_COVERAGE_LOG
 LOCAL_CFLAGS += -Werror -DRECORD_PSA_STATUS_COVERAGE_LOG
 endif
 
-.PHONY: generated_files
 GENERATED_BIGNUM_DATA_FILES := $(patsubst tests/%,%,$(shell \
 	$(PYTHON) ../framework/scripts/generate_bignum_tests.py --list || \
 	echo FAILED \
@@ -25,6 +24,17 @@ GENERATED_BIGNUM_DATA_FILES := $(patsubst tests/%,%,$(shell \
 ifeq ($(GENERATED_BIGNUM_DATA_FILES),FAILED)
 $(error "$(PYTHON) ../framework/scripts/generate_bignum_tests.py --list" failed)
 endif
+GENERATED_DATA_FILES += $(GENERATED_BIGNUM_DATA_FILES)
+
+GENERATED_CONFIG_DATA_FILES := $(patsubst tests/%,%,$(shell \
+	$(PYTHON) ../framework/scripts/generate_config_tests.py --list || \
+	echo FAILED \
+))
+ifeq ($(GENERATED_CONFIG_DATA_FILES),FAILED)
+$(error "$(PYTHON) ../framework/scripts/generate_config_tests.py --list" failed)
+endif
+GENERATED_DATA_FILES += $(GENERATED_CONFIG_DATA_FILES)
+
 GENERATED_ECP_DATA_FILES := $(patsubst tests/%,%,$(shell \
 	$(PYTHON) ../framework/scripts/generate_ecp_tests.py --list || \
 	echo FAILED \
@@ -32,6 +42,8 @@ GENERATED_ECP_DATA_FILES := $(patsubst tests/%,%,$(shell \
 ifeq ($(GENERATED_ECP_DATA_FILES),FAILED)
 $(error "$(PYTHON) ../framework/scripts/generate_ecp_tests.py --list" failed)
 endif
+GENERATED_DATA_FILES += $(GENERATED_ECP_DATA_FILES)
+
 GENERATED_PSA_DATA_FILES := $(patsubst tests/%,%,$(shell \
 	$(PYTHON) ../framework/scripts/generate_psa_tests.py --list || \
 	echo FAILED \
@@ -39,8 +51,13 @@ GENERATED_PSA_DATA_FILES := $(patsubst tests/%,%,$(shell \
 ifeq ($(GENERATED_PSA_DATA_FILES),FAILED)
 $(error "$(PYTHON) ../framework/scripts/generate_psa_tests.py --list" failed)
 endif
-GENERATED_FILES := $(GENERATED_PSA_DATA_FILES) $(GENERATED_ECP_DATA_FILES) $(GENERATED_BIGNUM_DATA_FILES)
-generated_files: $(GENERATED_FILES) src/test_keys.h src/test_certs.h
+GENERATED_DATA_FILES += $(GENERATED_PSA_DATA_FILES)
+
+GENERATED_FILES = $(GENERATED_DATA_FILES)
+GENERATED_FILES += src/test_keys.h src/test_certs.h
+
+.PHONY: generated_files
+generated_files: $(GENERATED_FILES)
 
 # generate_bignum_tests.py and generate_psa_tests.py spend more time analyzing
 # inputs than generating outputs. Its inputs are the same no matter which files
@@ -48,7 +65,6 @@ generated_files: $(GENERATED_FILES) src/test_keys.h src/test_certs.h
 # It's rare not to want all the outputs. So always generate all of its outputs.
 # Use an intermediate phony dependency so that parallel builds don't run
 # a separate instance of the recipe for each output file.
-.SECONDARY: generated_bignum_test_data generated_ecp_test_data generated_psa_test_data
 $(GENERATED_BIGNUM_DATA_FILES): $(gen_file_dep) generated_bignum_test_data
 generated_bignum_test_data: ../framework/scripts/generate_bignum_tests.py
 generated_bignum_test_data: ../framework/scripts/mbedtls_framework/bignum_common.py
@@ -60,6 +76,23 @@ generated_bignum_test_data: ../framework/scripts/mbedtls_framework/test_data_gen
 generated_bignum_test_data:
 	echo "  Gen   $(GENERATED_BIGNUM_DATA_FILES)"
 	$(PYTHON) ../framework/scripts/generate_bignum_tests.py
+.SECONDARY: generated_bignum_test_data
+
+# We deliberately omit the configuration files (mbedtls_config.h,
+# crypto_config.h) from the depenency list because during development
+# and on the CI, we often edit those in a way that doesn't change the
+# output, to comment out certain options, or even to remove certain
+# lines which do affect the output negatively (it will miss the
+# corresponding test cases).
+$(GENERATED_CONFIG_DATA_FILES): $(gen_file_dep) generated_config_test_data
+generated_config_test_data: ../framework/scripts/generate_config_tests.py
+generated_config_test_data: ../scripts/config.py
+generated_config_test_data: ../framework/scripts/mbedtls_framework/test_case.py
+generated_config_test_data: ../framework/scripts/mbedtls_framework/test_data_generation.py
+generated_config_test_data:
+	echo "  Gen   $(GENERATED_CONFIG_DATA_FILES)"
+	$(PYTHON) ../framework/scripts/generate_config_tests.py
+.SECONDARY: generated_config_test_data
 
 $(GENERATED_ECP_DATA_FILES): $(gen_file_dep) generated_ecp_test_data
 generated_ecp_test_data: ../framework/scripts/generate_ecp_tests.py
@@ -70,6 +103,7 @@ generated_ecp_test_data: ../framework/scripts/mbedtls_framework/test_data_genera
 generated_ecp_test_data:
 	echo "  Gen   $(GENERATED_ECP_DATA_FILES)"
 	$(PYTHON) ../framework/scripts/generate_ecp_tests.py
+.SECONDARY: generated_ecp_test_data
 
 $(GENERATED_PSA_DATA_FILES): $(gen_file_dep) generated_psa_test_data
 generated_psa_test_data: ../framework/scripts/generate_psa_tests.py
@@ -92,6 +126,7 @@ generated_psa_test_data: suites/test_suite_psa_crypto_metadata.data
 generated_psa_test_data:
 	echo "  Gen   $(GENERATED_PSA_DATA_FILES) ..."
 	$(PYTHON) ../framework/scripts/generate_psa_tests.py
+.SECONDARY: generated_psa_test_data
 
 # A test application is built for each suites/test_suite_*.data file.
 # Application name is same as .data file's base name and can be
@@ -99,7 +134,7 @@ generated_psa_test_data:
 DATA_FILES := $(wildcard suites/test_suite_*.data)
 # Make sure that generated data files are included even if they don't
 # exist yet when the makefile is parsed.
-DATA_FILES += $(filter-out $(DATA_FILES),$(GENERATED_FILES))
+DATA_FILES += $(filter-out $(DATA_FILES),$(GENERATED_DATA_FILES))
 APPS = $(basename $(subst suites/,,$(DATA_FILES)))
 
 # Construct executable name by adding OS specific suffix $(EXEXT).
diff --git a/tests/scripts/analyze_outcomes.py b/tests/scripts/analyze_outcomes.py
index eb2469495e9a..f8147d1dc11e 100755
--- a/tests/scripts/analyze_outcomes.py
+++ b/tests/scripts/analyze_outcomes.py
@@ -160,10 +160,10 @@ def analyze_driver_vs_reference(results: Results, outcomes: Outcomes,
         # don't issue an error if they're skipped with drivers,
         # but issue an error if they're not (means we have a bad entry).
         ignored = False
-        if full_test_suite in ignored_tests:
-            for str_or_re in ignored_tests[full_test_suite]:
-                if name_matches_pattern(test_string, str_or_re):
-                    ignored = True
+        for str_or_re in (ignored_tests.get(full_test_suite, []) +
+                          ignored_tests.get(test_suite, [])):
+            if name_matches_pattern(test_string, str_or_re):
+                ignored = True
 
         if not ignored and not suite_case in driver_outcomes.successes:
             results.error("PASS -> SKIP/FAIL: {}", suite_case)
@@ -242,6 +242,9 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'psa_crypto_low_hash.generated', # testing the builtins
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_(MD5|RIPEMD160|SHA[0-9]+)_.*'),
+                ],
                 'test_suite_platform': [
                     # Incompatible with sanitizers (e.g. ASan). If the driver
                     # component uses a sanitizer but the reference component
@@ -265,6 +268,10 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'psa_crypto_low_hash.generated',
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_(MD5|RIPEMD160|SHA[0-9]+)_.*'),
+                    re.compile(r'.*\bMBEDTLS_MD_C\b')
+                ],
                 'test_suite_md': [
                     # Builtin HMAC is not supported in the accelerate component.
                     re.compile('.*HMAC.*'),
@@ -304,6 +311,12 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'cipher',
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_(AES|ARIA|CAMELLIA|CHACHA20|DES)_.*'),
+                    re.compile(r'.*\bMBEDTLS_(CCM|CHACHAPOLY|CMAC|GCM)_.*'),
+                    re.compile(r'.*\bMBEDTLS_AES(\w+)_C\b.*'),
+                    re.compile(r'.*\bMBEDTLS_CIPHER_.*'),
+                ],
                 # PEM decryption is not supported so far.
                 # The rest of PEM (write, unencrypted read) works though.
                 'test_suite_pem': [
@@ -357,6 +370,9 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'ecdsa', 'ecdh', 'ecjpake',
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_(ECDH|ECDSA|ECJPAKE|ECP)_.*'),
+                ],
                 'test_suite_platform': [
                     # Incompatible with sanitizers (e.g. ASan). If the driver
                     # component uses a sanitizer but the reference component
@@ -397,6 +413,10 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'ecp', 'ecdsa', 'ecdh', 'ecjpake',
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_(ECDH|ECDSA|ECJPAKE|ECP)_.*'),
+                    re.compile(r'.*\bMBEDTLS_PK_PARSE_EC_COMPRESSED\b.*'),
+                ],
                 'test_suite_platform': [
                     # Incompatible with sanitizers (e.g. ASan). If the driver
                     # component uses a sanitizer but the reference component
@@ -436,6 +456,11 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'bignum.generated', 'bignum.misc',
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_BIGNUM_C\b.*'),
+                    re.compile(r'.*\bMBEDTLS_(ECDH|ECDSA|ECJPAKE|ECP)_.*'),
+                    re.compile(r'.*\bMBEDTLS_PK_PARSE_EC_COMPRESSED\b.*'),
+                ],
                 'test_suite_platform': [
                     # Incompatible with sanitizers (e.g. ASan). If the driver
                     # component uses a sanitizer but the reference component
@@ -485,6 +510,13 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                     # provide), even with MBEDTLS_USE_PSA_CRYPTO.
                     re.compile(r'PSK callback:.*\bdhe-psk\b.*'),
                 ],
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_BIGNUM_C\b.*'),
+                    re.compile(r'.*\bMBEDTLS_DHM_C\b.*'),
+                    re.compile(r'.*\bMBEDTLS_(ECDH|ECDSA|ECJPAKE|ECP)_.*'),
+                    re.compile(r'.*\bMBEDTLS_KEY_EXCHANGE_DHE_PSK_ENABLED\b.*'),
+                    re.compile(r'.*\bMBEDTLS_PK_PARSE_EC_COMPRESSED\b.*'),
+                ],
                 'test_suite_platform': [
                     # Incompatible with sanitizers (e.g. ASan). If the driver
                     # component uses a sanitizer but the reference component
@@ -523,6 +555,9 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
             'component_driver': 'test_psa_crypto_config_accel_ffdh',
             'ignored_suites': ['dhm'],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_DHM_C\b.*'),
+                ],
                 'test_suite_platform': [
                     # Incompatible with sanitizers (e.g. ASan). If the driver
                     # component uses a sanitizer but the reference component
@@ -545,6 +580,15 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'bignum.generated', 'bignum.misc',
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_BIGNUM_C\b.*'),
+                    re.compile(r'.*\bMBEDTLS_(ASN1\w+)_C\b.*'),
+                    re.compile(r'.*\bMBEDTLS_(ECDH|ECDSA|ECP)_.*'),
+                    re.compile(r'.*\bMBEDTLS_PSA_P256M_DRIVER_ENABLED\b.*')
+                ],
+                'test_suite_config.crypto_combinations': [
+                    'Config: ECC: Weierstrass curves only',
+                ],
                 'test_suite_platform': [
                     # Incompatible with sanitizers (e.g. ASan). If the driver
                     # component uses a sanitizer but the reference component
@@ -570,6 +614,10 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'pk', 'pkwrite', 'pkparse'
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_(PKCS1|RSA)_.*'),
+                    re.compile(r'.*\bMBEDTLS_GENPRIME\b.*')
+                ],
                 'test_suite_platform': [
                     # Incompatible with sanitizers (e.g. ASan). If the driver
                     # component uses a sanitizer but the reference component
@@ -611,6 +659,10 @@ def do_analyze_driver_vs_reference(results: Results, outcomes: Outcomes, args) -
                 'cipher.camellia',
             ],
             'ignored_tests': {
+                'test_suite_config': [
+                    re.compile(r'.*\bMBEDTLS_(AES|ARIA|CAMELLIA)_.*'),
+                    re.compile(r'.*\bMBEDTLS_AES(\w+)_C\b.*'),
+                ],
                 'test_suite_cmac': [
                     # Following tests require AES_C/ARIA_C/CAMELLIA_C to be enabled,
                     # but these are not available in the accelerated component.
diff --git a/tests/scripts/check-generated-files.sh b/tests/scripts/check-generated-files.sh
index e740f33865a1..09c850af7ad6 100755
--- a/tests/scripts/check-generated-files.sh
+++ b/tests/scripts/check-generated-files.sh
@@ -129,6 +129,7 @@ check()
 # These checks are common to Mbed TLS and TF-PSA-Crypto
 check scripts/generate_psa_constants.py programs/psa/psa_constant_names_generated.c
 check framework/scripts/generate_bignum_tests.py $(framework/scripts/generate_bignum_tests.py --list)
+check framework/scripts/generate_config_tests.py $(framework/scripts/generate_config_tests.py --list)
 check framework/scripts/generate_ecp_tests.py $(framework/scripts/generate_ecp_tests.py --list)
 check framework/scripts/generate_psa_tests.py $(framework/scripts/generate_psa_tests.py --list)
 check framework/scripts/generate_test_keys.py tests/src/test_keys.h
diff --git a/tests/suites/test_suite_config.crypto_combinations.data b/tests/suites/test_suite_config.crypto_combinations.data
new file mode 100644
index 000000000000..d3287d266a3b
--- /dev/null
+++ b/tests/suites/test_suite_config.crypto_combinations.data
@@ -0,0 +1,9 @@
+# Interesting combinations of low-level crypto options
+
+Config: ECC: Weierstrass curves only
+depends_on:MBEDTLS_ECP_SHORT_WEIERSTRASS_ENABLED:!MBEDTLS_ECP_MONTGOMERY_ENABLED
+pass:
+
+Config: ECC: Montgomery curves only
+depends_on:!MBEDTLS_ECP_SHORT_WEIERSTRASS_ENABLED:MBEDTLS_ECP_MONTGOMERY_ENABLED
+pass:
diff --git a/tests/suites/test_suite_config.function b/tests/suites/test_suite_config.function
new file mode 100644
index 000000000000..9e9dd019906c
--- /dev/null
+++ b/tests/suites/test_suite_config.function
@@ -0,0 +1,14 @@
+/* BEGIN_HEADER */
+
+/* END_HEADER */
+
+/* BEGIN_CASE */
+/* This test case always passes. It is intended solely for configuration
+ * reporting in the outcome file. Write test cases using this function
+ * with dependencies to record in which configurations the dependencies
+ * are met. */
+void pass()
+{
+    goto exit;
+}
+/* END_CASE */
diff --git a/tests/suites/test_suite_config.psa_combinations.data b/tests/suites/test_suite_config.psa_combinations.data
new file mode 100644
index 000000000000..1035af248702
--- /dev/null
+++ b/tests/suites/test_suite_config.psa_combinations.data
@@ -0,0 +1,9 @@
+# Interesting combinations of PSA options
+
+Config: PSA_WANT_ALG_ECDSA without PSA_WANT_ALG_DETERMINISTIC_ECDSA
+depends_on:PSA_WANT_ALG_ECDSA:!PSA_WANT_ALG_DETERMINISTIC_ECDSA
+pass:
+
+Config: PSA_WANT_ALG_DETERMINSTIC_ECDSA without PSA_WANT_ALG_ECDSA
+depends_on:PSA_WANT_ALG_DETERMINISTIC_ECDSA:!PSA_WANT_ALG_ECDSA
+pass:
diff --git a/tests/suites/test_suite_config.tls_combinations.data b/tests/suites/test_suite_config.tls_combinations.data
new file mode 100644
index 000000000000..cbc57d6cd3c6
--- /dev/null
+++ b/tests/suites/test_suite_config.tls_combinations.data
@@ -0,0 +1,9 @@
+# Interesting combinations of TLS options
+
+Config: TLS 1.2 without TLS 1.3
+depends_on:MBEDTLS_SSL_PROTO_TLS1_2:!MBEDTLS_SSL_PROTO_TLS1_3
+pass:
+
+Config: TLS 1.3 without TLS 1.2
+depends_on:MBEDTLS_SSL_PROTO_TLS1_3:!MBEDTLS_SSL_PROTO_TLS1_2
+pass: